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Background The polyvalent acidic lipid phosphatidylinositol, 4,5- bis phosphate (PIP 2 ) is important for many cellular functions. It has been suggested that different pools of PIP 2 exist in the cytoplasmic leaflet of the plasma membrane, and that such pooling could play a role in the regulation of PIP 2 . The mechanism of fencing, however,...
Determining an accurate initial native-like protein fold is one of the most important and time-consuming steps of de novo NMR structure determination. Here we demonstrate that high-quality native-like models can be rapidly generated from initial structures obtained using limited NOE assignments, through replica exchange molecular dynamics refinement with a generalized Born implicit solvent (REX/GB)...
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