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Reverse‐phase high‐performance liquid chromatography method has been developed for the determination of brivaracetam stereoisomeric impurities such as (R,S)‐brivaracetam, (R,R)‐brivaracetam, and (S,S)‐brivaracetam with good resolution using the chiral column, Chiral PAK IG‐U (100 × 3.0 mm; 1.6 μm). The method is simple, stability‐indicating, and compatible with LC–MS. The separation was achieved with...
Chiral salalen ligands derived from (S)‐proline and derivatives of salicyaldehydes were synthesized, and their in‐situ generated Cu (II) complexes were evaluated in the asymmetric Henry reaction. Salalen ligand of different substituents on the phenyl moiety showed remarkable effect on the enantioselectivity of nitro‐aldol product of 4‐nitrobenzaldehyde and nitromethane. Cu (II) complex generated in...
Nuclear magnetic resonance (NMR) technique has been used to find the property of atropisomerism in Rilpivirine hydrochloride by variable temperature analysis and various 2D techniques. Both the Rilpivirine hydrochloride (E‐isomer) and Impurity‐A (Z‐isomer) isomers have been differentiated and confirmed by NMR and ultraviolet techniques. Preparative high‐performance liquid chromatography isolation...
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