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Background: B cells in tonsil, which may produce the nephritogenic IgA, have been incriminated in the pathogenesis of IgAN. The aim of the present study was to assess the role of memory B cell in clinical progression of IgAN. Methods we investigated 28 IgAN patients and 27 age-matched patients with chronic tonsillitis without IgAN, who were treated by tonsillectomy, meanwhile, the peripheral blood...
Recognition of nucleic acids by TLR9 expressed by human plasmacytoid dendritic cells (PDC) plays a key role in the defense against viral infections. Upon microbial pathogen stimulation, PDC secrete large amounts of type I interferon and arbitrate thereby both innate and adaptive immune mechanisms. Unmethylated CpG motifs, which are an integral part of bacterial or viral DNA, are used in vitro and...
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