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Brain sodium channels are complexes of a pore-forming α subunit with auxiliary β subunits, which are transmembrane proteins that modulate α subunit function. The newly cloned β3 subunit is shown to be expressed broadly in neurons in the central and peripheral nervous systems, but not in glia and most nonneuronal cells. β1, β2, and β3 subunits are coexpressed in many neuronal cell types, but are differentially...
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