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The recently reported α1D Ca channel in the heart is known to be regulated by protein kinase C (PKC) at the whole cell level and has been implicated in atrial fibrillation. The biophysical basis of this regulation at the single-channel level is not known. Therefore, the effect of PKC activation was studied on α1D Ca channel expressed in tsA201 cells using cell-attached configuration. Unitary currents...
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