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MDMA (3,4-methylenedioxymethamphetamine, ''Ecstasy'') mainly releases serotonin and dopamine. In animals, pretreatment with 5-HT 2 antagonists has been shown to attenuate neurochemical and behavioral effects of MDMA. In humans, the role of 5-HT 2 receptors in the action of MDMA has not been studied. We investigated the effect of pretreatment with the 5-HT 2A/C ...
[H 215 O]-Positron Emission Tomography (PET) was used to examine regional cerebral blood flow (rCBF) after administration of a single oral dose of the serotonin realeaser and uptake inhibitor MDMA (1.7 mg/kg) or placebo to 16 MDMA-nave subjects. Psychological changes were assessed by psychometric rating scales. MDMA produced distributed changes in regional blood flow including increases...
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