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Infection by the four serotypes of Dengue virus (DENV‐1 to DENV‐4) causes an important arthropod‐borne viral disease in humans. The multifunctional DENV nonstructural protein 5 (NS5) is essential for capping and replication of the viral RNA and harbours a methyltransferase (MTase) domain and an RNA‐dependent RNA polymerase (RdRp) domain. In this study, insights into the overall structure and flexibility...
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