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The interferon-beta (IFNβ) gene is not inducible in neuronal cells in response to measles virus (MV) due to lack of nuclear factor kappa B (NF-κB) activation. NF-κB is normally sequestered in the cytoplasm by an inhibitor (IκBα). Previously, the authors demonstrated that the failure to activate neuronal NF-κB by MV was due to the inability to phosphorylate and degrade its inhibitor, IκBα. Here the...
Lack of IFN-β and MHC class I expression in measles virus (MV) infected neurons could impair the host antiviral defense mechanism and result in virus escape from recognition by cytotoxic T-cells. Induction of IFN-β and MHC class I gene expression requires NF-κB activation which depends on degradation of IκBα, an inhibitory protein of NF-κB. In earlier studies we demonstrated that in contrast to glial...
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