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Capicua, encoded by the gene CIC, is an evolutionarily conserved high‐mobility group‐box transcription factor downstream of the receptor tyrosine kinase and mitogen‐activated protein kinase pathways. It was initially discovered and studied in Drosophila. Recurrent mutations in CIC were first identified in oligodendroglioma, a subtype of low‐grade glioma. Subsequent studies have identified CIC aberrations...
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