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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor dysfunction and loss of large motor neurons in the spinal cord and brain stem. While much research has focused on mechanisms of motor neuron cell death in the spinal cord, degenerative processes in skeletal muscle and neuromuscular junctions (NMJs) are also observed early in disease development...
Leukotriene A 4 (LTA 4 ) hydrolase is essential for the conversion of LTA 4 to LTB 4 , an inflammatory lipid mediator. We investigated whether LTA 4 hydrolase was regulated in the heart by angiotensin II (ang II) infusion. Continuous ang II infusion via an osmotic minipump for up to 7 days upregulated mRNA and protein levels of LTA 4 hydrolase (~3.5-fold...
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