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Results of studies from our laboratory have shown that administration of 17β-estradiol (E 2 ) reduces cerebellar neuronal damage during ethanol withdrawal (EW). In the current study, we investigated whether the GABAergic system is involved in the protective effects of E 2 against the EW syndrome. To test this hypothesis, we examined the effects of GABAergic drugs, with and without...
Results of studies from our laboratory have shown that administration of 17β-estradiol (E 2 ) reduces cerebellar neuronal damage during ethanol withdrawal (EW). In the current study, we examined mechanisms underlying E 2 protection against EW-associated cerebellar damage by assessing apoptotic indicators: DNA fragmentation, caspase-3 activity, and protein kinase C (PKC) activity. Ovariectomized...
On the basis of findings obtained from this study, we hypothesize that the female sex steroid 17β-estradiol (E 2 ) protects against cerebellar neuronal damage and behavioral deficit in rats withdrawn from chronic ethanol exposure. Ovariectomized rats implanted with E 2 or an oil pellet received liquid ethanol (7.5% [wt./vol.]) or dextrin diet for 5 weeks, followed by 2 weeks of ethanol...
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