Search results for: Xinhua Hu

Items from 1 to 20 out of 41 results

article

A new simple method for quantification of cilostazol and its active metabolite in human plasma by LC–MS/MS: Application to pharmacokinetics of cilostazol associated with CYP genotypes in healthy Chinese population

Yuting Shen, Bo Jiang, Xinhua Hu, Jinliang Chen, more

Biomedical Chromatography > 35 > 10 > n/a - n/a

A simple, sensitive, and fully automated liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous quantification of cilostazol (CIL) and its active metabolite, 3,4‐dehydro cilostazol (CIL‐M), in human plasma. Plasma samples were processed by protein precipitation in 2 mL 96‐deep‐well plates, and all liquid transfer steps were performed through...

article

Development of LC‐MS/MS determination method and backpropagation artificial neural networks pharmacokinetic model of febuxostat in healthy subjects

Yichao Xu, Jinliang Chen, Dandan Yang, Yin Hu, more

Journal of Clinical Pharmacy and Therapeutics > 46 > 2 > 333 - 342

What is known and objective Febuxostat is a well‐known drug for treating hyperuricemia and gout. The published methods for determination of febuxostat in human plasma might be unsuitable for high‐throughput determination and widespread application. We need to develop a highly selective, sensitive and rapid liquid chromatography‐tandem mass spectrometry method. Methods The chromatographic separation...

article

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Guanjie Hu, Xinhua Hu, Kun Yang, Dongming Liu, more

Human Brain Mapping > 41 > 7 > 1786 - 1796

Glioma can cause variable alterations to the structure and function of the brain. However, there is a paucity of studies on the gray matter (GM) volume alterations in the brain region opposite the temporal glioma before and after surgery. Therefore, the present study was initiated to investigate the alternation in contralateral homotopic GM volume in patients with unilateral temporal lobe glioma and...

article

Retracted: Downregulated long noncoding RNA LINC00313 inhibits the epithelial–mesenchymal transition, invasion, and migration of thyroid cancer cells through inhibiting the methylation of ALX4

Xingzhi Zhao, Xinhua Hu

Journal of Cellular Physiology > 234 > 11 > 20992 - 21004

Thyroid cancer represents one of the prevalent endocrine cancer with relatively high incidence rate around the world, accompanied by unchanged fatality rate. We probe into the specific role of LINC00313 in mediation of cellular processes of thyroid cancer including proliferation, migration, and invasion through the methylation of aristaless‐like homeobox 4 (ALX4). Thyroid cancer‐related long noncoding...

article

Uric acid in aortic dissection: A meta-analysis

Xiaodong Li, Shanshan Jiang, Jiaan He, Nan Li, more

Clinica Chimica Acta > 2018 > 484 > C > 253-257

Studies on the serum uric acid levels in patients with aortic dissection have yielded conflicting results.To compare the difference in serum uric acid (SUA) levels between aortic dissection patients and controls by meta-analysis.Electronic literature search was conducted in PubMed, Embase, CKNI, CBM, Wanfang, and VIP databases until January 31, 2018. All observational studies that investigated SUA...

article

Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis

Xinhua Hu, Xing Ji, Mengting Yang, Shihao Fan, more

Journal of Bone and Mineral Research > 33 > 5 > 945 - 958

Cdc42, a member of Rho family small guanosine triphosphatases (GTPases), is critical for cartilage development. We investigated the roles of Cdc42 in osteoarthritis and explored the potential mechanism underlying Cdc42‐mediated articular cartilage degeneration and subchondral bone deterioration. Cdc42 is highly expressed in both articular cartilage and subchondral bone in a mouse osteoarthritis model...

article

Cardiac troponin and adverse outcomes in atrial fibrillation: A meta-analysis

Yichuan Fan, Xingzhi Zhao, Xiaodong Li, Nan Li, more

Clinica Chimica Acta > 2018 > 477 > C > 48-52

The prognostic value of cardiac troponin elevation in atrial fibrillation (AF) is unclear.To investigate the association of cardiac troponin elevation with adverse outcomes in AF by conducting a meta-analysis.We systematically searched the PubMed and Embase databases until April 2017 for studies assessing the association of cardiac troponin-T (cTnT) or troponin-I (cTnI) elevation with adverse outcomes...

article

Vitamin C deficiency exacerbates diabetic glomerular injury through activation of transforming growth factor-β signaling

Xing Ji, Xinhua Hu, Chaochun Zou, Hongfeng Ruan, more

Biochimica et Biophysica Acta (BBA) - General Subjects > 2017 > 1861 > 9 > 2186-2195

The hyperglycemia and hyperoxidation that characterize diabetes lead to reduced vitamin C (VC) in diabetic humans and experimentally diabetic animals. Herein, we access the effects of VC deficiency on the diabetic kidney injury and explore the underlying mechanism.l-gulonolactone oxidase conventional knockout (Gulo^−/−) mice genetically unable to synthesize VC were subjected to streptozotocin-induced...

article

Inhibition of heat shock protein 90 rescues glucocorticoid-induced bone loss through enhancing bone formation

Haixiao Chen, Ji Xing, Xinhua Hu, Lihua Chen, more

The Journal of Steroid Biochemistry and Molecular Biology > 2017 > 171 > C > 236-246

Endogenous glucocorticoids (GCs) support normal bone development and bone mass maintenance, whereas long-term exposure to pharmacological dosages of GCs uncouples bone formation and resorption, resulting in GC-induced osteoporosis (GIOP). Heat shock protein 90 (HSP90) chaperoning glucocorticoid receptor (GR) signaling prompts us to speculate that HSP90 plays critical roles in GC-mediated bone formation...

chapter

Broadband focusing and collimation of water waves by zero refractive index

Chi Zhang, C. T. Chan, Xinhua Hu

2016 Progress in Electromagnetic Research Symposium (PIERS) > 3117

2016 Progress in Electromagnetic Research Symposium (PIERS)

It is always a challenge to realize extreme and unusual values of refractive index for a broad range of frequencies. We show that when water is covered by a thick, rigid and unmovable plate, it behaves like a medium with zero refractive index for water waves at any frequency. Hence, by covering water with a plate of a concave or rectangular shape, water waves can be focused or collimated in a broad...

article

Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway

Naihua Liu, Liu Mei, Xueying Fan, Chao Tang, more

Cancer Letters > 2016 > 378 > 1 > 38-50

Cancer stem cells (CSC) are critical for initiation, metastasis, and relapse of cancers, however, the underlying mechanism governing stemness of CSC remains unknown. Herein, we have investigated the roles of phosphodiesterase 5 (PDE5) in stemness of prostate cancer cells. Both PDE5 and WW domain-containing transcription regulator protein-1 (TAZ), a core effector of Hippo pathway, are highly expressed...

article

Effect of clinical nursing pathway for endoscopic thyroidectomy in Chinese patients: A meta‐analysis

Yu Yang, Xinhua Hu, Qiang Zhang, Hui Cao, more

International Journal of Nursing Practice > 22 > 3 > 224 - 231

The aim of this study was to assess the effect of the use of a clinical nursing pathway for patients undergoing endoscopic thyroidectomy by conducting a meta‐analysis. Electronic databases were searched for relevant controlled trials published prior to August 2013. Only papers that compared the use of a clinical nursing pathway to usual care for patients undergoing endoscopic thyroidectomy were selected...

article

Usual walking speed and all-cause mortality risk in older people: A systematic review and meta-analysis

Bing Liu, Xinhua Hu, Qiang Zhang, Yichuan Fan, more

Gait & Posture > 2016 > 44 > C > 172-177

The purpose of this study was to investigate the relationship between slow usual walking speed and all-cause mortality risk in older people by conducting a meta-analysis. We searched through the Pubmed, Embase and Cochrane Library database up to March 2015. Only prospective observational studies that investigating the usual walking speed and all-cause mortality risk in older adulthood approaching...

article

Influence of electric-hydraulic chattering on forward extrusion process

Xinhua Hu, Qinghua Yang, Zhiheng Wang, Guanjun Bao, more

The International Journal of Advanced Manufacturing Technology > 2016 > 82 > 9-12 > 1475-1484

Vibration-assisted metal forming is one of the most recent and beneficial techniques used to improve material flow of the forming process. However, some technical challenges, such as the large power requirement of vibration generation and technical complexity of the metal forming process control, are difficult to solve. The main objective of this work is to investigate the possibility of applying...

article

Increased risk of venous thromboembolism in patients with brain tumors: A systematic review and meta-analysis

Chunfa Qian, Hua Yan, Xinhua Hu, Wenbin Zhang, more

Thrombosis Research > 2016 > 137 > C > 58-63

Currently published studies investigating the association between brain tumors and venous thromboembolism (VTE) risk have yielded inconsistent findings. To provide a more precise estimate for this association, we firstly performed a meta-analysis by pooling all currently available data.Pooled relative risks (RRs) with 95% confidence intervals (95% CIs) were calculated by use of STATA 12.0 software...

article

Serum uric acid as a predictor for cardiovascular and all-cause mortality in women versus men

Yu Yang, Yichuan Fan, Jun Li, Bing Liu, more

International Journal of Cardiology > 2015 > 185 > Complete > 125-128

article

X-ray differential phase-contrast tomographic reconstruction with a phase line integral retrieval filter

Jian Fu, Xinhua Hu, Chen Li

Nuclear Instruments and Methods in Physics Research Section A: Accelerators,... > 2015 > 778 > C > 14-19

We report an alternative reconstruction technique for x-ray differential phase-contrast computed tomography (DPC-CT). This approach is based on a new phase line integral projection retrieval filter, which is rooted in the derivative property of the Fourier transform and counteracts the differential nature of the DPC-CT projections. It first retrieves the phase line integral from the DPC-CT projections...

article

Does elevated asymmetrical dimethylarginine predict major adverse cardiac events and mortality in patients after percutaneous coronary intervention?

Yang Shao, Yichuan Fan, Jun Li, Hui Cao, more

International Journal of Cardiology > 2015 > 178 > Complete > 188-190

article

The Immunoprotective Activity of Baicalin in Mouse Model of Cecal Ligation and Puncture-Induced Sepsis

Xinhua Hu, Peizhi Miao, Ronghuan Yu, Hongchao Zheng

Cell Biochemistry and Biophysics > 2015 > 71 > 2 > 543-547

The purpose of the study was to probe the therapeutic effect of baicalin on immunosuppression in the mouse model of cecal ligation and puncture (CLP)-induced sepsis. Mouse model was established by employing the procedure of CLP. The proliferation of T lymphocytes was measured using CFDA-SE staining and MTT method, and the proliferation index was determined to assess the proliferation status of the...

article

Upregulation of let-7a inhibits vascular smooth muscle cell proliferation in vitro and in vein graft intimal hyperplasia in rats

Hui Cao, Xinhua Hu, Qiang Zhang, Junpeng Wang, more

Journal of Surgical Research > 2014 > 192 > 1 > 223-233

Proliferation of vascular smooth muscle cells (VSMCs) is a crucial event in the pathogenesis of intimal hyperplasia, which is the main cause of restenosis after vascular reconstruction. In this study, we assessed the impact of let-7a microRNA (miRNA) on the proliferation of VSMCs.Using miRNA microarrays analysis for miRNA expression in the vein graft model. Lentiviral vector-mediated let-7a was transfected...

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INFONA - science communication portal

Search results for: Xinhua Hu

A new simple method for quantification of cilostazol and its active metabolite in human plasma by LC–MS/MS: Application to pharmacokinetics of cilostazol associated with CYP genotypes in healthy Chinese population

Development of LC‐MS/MS determination method and backpropagation artificial neural networks pharmacokinetic model of febuxostat in healthy subjects

Restructuring of contralateral gray matter volume associated with cognition in patients with unilateral temporal lobe glioma before and after surgery

Retracted: Downregulated long noncoding RNA LINC00313 inhibits the epithelial–mesenchymal transition, invasion, and migration of thyroid cancer cells through inhibiting the methylation of ALX4

Uric acid in aortic dissection: A meta-analysis

Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis

Cardiac troponin and adverse outcomes in atrial fibrillation: A meta-analysis

Vitamin C deficiency exacerbates diabetic glomerular injury through activation of transforming growth factor-β signaling

Inhibition of heat shock protein 90 rescues glucocorticoid-induced bone loss through enhancing bone formation

Broadband focusing and collimation of water waves by zero refractive index

Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway

Effect of clinical nursing pathway for endoscopic thyroidectomy in Chinese patients: A meta‐analysis

Usual walking speed and all-cause mortality risk in older people: A systematic review and meta-analysis

Influence of electric-hydraulic chattering on forward extrusion process

Increased risk of venous thromboembolism in patients with brain tumors: A systematic review and meta-analysis

Serum uric acid as a predictor for cardiovascular and all-cause mortality in women versus men

X-ray differential phase-contrast tomographic reconstruction with a phase line integral retrieval filter

Does elevated asymmetrical dimethylarginine predict major adverse cardiac events and mortality in patients after percutaneous coronary intervention?

The Immunoprotective Activity of Baicalin in Mouse Model of Cecal Ligation and Puncture-Induced Sepsis

Upregulation of let-7a inhibits vascular smooth muscle cell proliferation in vitro and in vein graft intimal hyperplasia in rats

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