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We examined the effects of peroxynitrite pre-treatment on sarco/endoplasmic reticulum Ca 2+ (SERCA) pump in pig coronary artery smooth muscle and endothelium. In saponin-permeabilized cells, smooth muscle showed much greater rates of the SERCA Ca 2+ pump-dependent 45 Ca 2+ uptake/mg protein than did the endothelial cells. Peroxynitrite treatment...
Objective: H 2 O 2 can contract many arteries, however the underlying mechanisms are not fully understood. This study aims to test whether H 2 O 2 -induced vasoconstriction could be functionally attributed to the activation of P 2 -purinoceptors in rat aorta and to explore its possible signaling mechanisms. Methods: Isometric tension recording of H 2 ...
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