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The effects of a newly discovered antifungal agent, pramanicin, on cytosolic Ca 2+ and cell viability of cultured bovine pulmonary artery endothelial cells and on endothelium-dependent relaxation of dog carotid arterial rings were investigated by digital dynamic fluorescence ratio imaging and morphological and contractility studies, respectively. Pramanicin 100 μM, previously shown to...
Leonurine, a plant alkaloid present in Chinese motherwort, induced concentration- dependent and endothelium-independent relaxation of phenylephrine (PE)- pretreated rat aortic arterial rings. The IC 50 values for leonurine were 86.4+/-10.4 and 85.9+/-17.2 μM in the presence and absence of endothelium respectively. It inhibited the responses of aortic smooth muscle to PE in Ca 2 ...
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