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Sixteen derivatives of N-acetyl-3-O-methyldopamine (NAMDA), an inhibitor of BH 4 synthesis, were designed and synthesized. The ability of these derivatives to inhibit NO and BH 4 production by lipopolysaccharide-stimulated BV-2 microglial cells was determined. While NAMDA at 100μM inhibited NO and BH 4 production by only about 20%, its catecholamide 8, indole 23 derivative,...
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