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Macrophage foam cells are central in the development of atherosclerosis, but the mechanism of foam cell formation is unclear. Toll-like receptor 4 (TLR4) signaling is known to participate in the pathogenesis of atherosclerosis. Further, oxidized low density lipoprotein (oxLDL) enhances TLR4 expression in macrophages. We hypothesized that TLR4 mediates macrophage differentiation to foam cells.Peritoneal...
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