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The urokinase plasminogen axis is composed of urokinase plasminogen activator (uPA), its receptor (uPAR), and its inhibitors (PAI-1 and PAI-2). This axis is involved in cell proliferation, angiogenesis, extracellular matrix degradation, invasion, and metastases.To assess the relationship of the uPA axis with pathologic features and outcomes in prostate cancer.Retrospective study of 230 consecutive...
We hypothesized that either very low (0–2.5ng/mL) or very high (>20ng/mL) PSA values may limit the accuracy of pathological stage predictions. To test this hypothesis, we examined 5193 consecutive patients subjected to radical prostatectomy (RP) for localized prostate cancer (PCa).Patients were divided into three cohorts according to their pre-treatment PSA value: ≤2.5 (n=331), 2.51–20 (n=4545)...
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