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Purpose The purpose of this study was to investigate the short-term signaling effects of St. John’s Wort (SJW) extract and selected SJW constituents on the blood-brain barrier transporter P-glycoprotein and to describe the role of PKC in the signaling. Methods Cultured porcine brain capillary endothelial cells (PBCEC) and freshly isolated brain capillaries from pig were used as in vitro/ex vivo...
We report on a cost- and time-effective fluorescent dye (calcein–acetoxymethylester; calcein–AM)-based assay to screen compounds for p-glycoprotein (p-gp) interactions at the blood–brain barrier. This assay enables the use of freshly isolated or freshly defrosted endothelial cells without prior cell culture. Isolated porcine brain capillary endothelial cells (PBCECs) in suspension were exposed to...
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