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Previously, we showed that activation of the β-catenin/Wnt pathway is a dominant event during c-Myc/E2F1 hepatocarcinogenesis. Majority of c-Myc/E2F1 HCCs displayed nuclear accumulation of β-catenin in the absence of β-catenin mutations, suggesting that alterations in other members of the Wnt pathway might be responsible for nuclear localization of β-catenin. Here, we investigated the mechanisms responsible...
Co-expression of c-Myc and TGF-α in the mouse liver accelerates hepatocarcinogenesis and enhances DNA damage due to chronic oxidative stress. Dietary supplementation with vitamin E (VE) inhibits hepatocarcinogenesis and reduces chromosomal alterations in the same mice. Here we investigated the sources of reactive oxygen species (ROS) production in c-Myc/TGF-α transgenic mice.Inducible nitric oxide...
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