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Investigating intracerebral tissue at single cell level has become increasingly important in animal studies and meanwhile found its way into clinical applications. The stability of single unit activity (SUA) to be recorded can be however quite elusive, which -among others- might be caused by the mechanical mismatch of stiff neural implants and soft brain tissue. Unfortunately, the variety of factors...
This paper reports on the design, fabrication, and characterization of neural probes for stereoelectroencephalography (SEEG). The probe specifically targets focal epilepsy as key application. However, probes of this type can also be used for the diagnosis and treatment of other neural dysfunctions such as Parkinson's disease or tremor, typically requiring deep brain probes. The probe fabrication,...
Multi-electrode arrays for in vivo neural recording are presented incorporating the principle of electronic depth control, i.e. an electronic selection of electrode locations along the probe shaft independently for multiple channels. Two-dimensional (2D) arrays are realized using a commercial CMOS process for the electronic circuits combined with post-CMOS micromachining for shaping the probes and...
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