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This study was designed to evaluate whether or not continuous intracerebroventricular infusion of leptin (1.5μg/rat/24h, for 28 days) produced different regional response on the skeleton of growing rats. Leptin reduce the accretion of total femoral bone mineral content (BMC) and density (BMD). This effect was related to a reduction of metaphyseal femur as no changes were detected in the diaphysis...
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