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Granular structures that are recognized by antibodies specific for the C-terminal but not the N-terminal sequences of the β-amyloid protein (Aβ) fragments are present in a subset of microglia and astrocytes in Alzheimer brain tissue. The immunohistochemical profile indicates that the Aβ in these granules is truncated between the residues 17 and 31 and terminates at the residue 42 or 43. Such granule-containing...
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