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Determination of muscarinic agonist-induced parasympathomimetic effects in wild type and M 2 and M 4 muscarinic receptor knockout mice revealed that M 2 receptors mediated tremor and hypothermia, but not salivation. The M 4 receptors seem to play a modest role in salivation, but did not alter hypothermia and tremor. In the M 2 knockout mice, agonist-induced...
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