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Cell–matrix interactions govern cell behavior and tissue function by facilitating transduction of biomechanical cues. Engineered tissues often incorporate these interactions by employing cell‐adhesive materials. However, using constitutively active cell‐adhesive materials impedes control over cell fate and elicits inflammatory responses upon implantation. Here, an alternative cell–material interaction...
Cell–Material Tethering
Cells need to sense their environment in order to survive and function. In article number 2102660, Tom Kamperman, Jeroen Leijten, and co‐workers present an enzymatic crosslinking strategy that can tether non‐cell‐adhesive materials to cells. By targeting the cellular adhesome, this cell–material tethering method enables cell‐volume‐independent lineage programming of stem cells...
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