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HCN4 channels are considered to be a promising target for cardiac pathologies, epilepsy, and multiple sclerosis. However, there are no subtype‐selective HCN channel blockers available, and only a few compounds are reported to display subtype preferences, one of which is EC18 (cis‐1). Herein, we report the optimized synthetic route for the preparation of EC18 and its evaluation in three different pharmacological...
Autoimmune central nervous system (CNS) inflammation occurs both in a paraneoplastic and non-paraneoplastic context. In a widening spectrum of clinical disorders, the underlying adaptive (auto) immune response targets neurons with a divergent role for cellular and humoral disease mechanisms: (1) in encephalitis associated with antibodies to intracellular neuronal antigens, neuronal antigen-specific...
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