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Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H 2 O 2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H 2 O 2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and ICI 174864. High concentrations of both...
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