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Tablets of three different grades of hydroxypropyl methyl cellulose (HPMC), having different viscosity, were prepared using the direct-compression technique with no additive or binder. The fluid uptake behavior of these HPMC tablets was studied in three types of bio-media – water, simulated gastric fluid (SGF), and simulated intestinal fluid (SIF). The amount of fluid uptake by the tablets followed...
The thermoreversible gelation of hydroxypropylmethylcellulose (HPMC) in simulated intestinal/gastric fluids (SIF/SGF) was monitored by microcalorimetry (micro-DSC), turbidity and rheometry. Both SGF and SIF facilitated sol–gel transition in HPMC without changing the patterns of gelation behavior. The sol–gel transition was found to be an entropy driven and temperature dependent process. Solution isotopic...
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