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Pathology in ALS spreads within the brain along tracts which are connected to the primary motor cortex, eventually causing atrophy in several cortical areas. Grey and white matter signals in high resolution T1 MRI can be analyzed using i.e. cortical thickness analyses, voxel-based morphometry (VBM), voxel-based intensitometry (VBI), deformation based mapping and other T1 tools. These tools are capable...
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