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Previous studies have suggested that some graph properties of protein interaction networks might be related with gene morbidity. In particular, it has been suggested that when a polymorphism affects a gene, it is more likely to produce a disease if the node degree in the interaction network is higher than for other genes. However, these results do not take into account the possible bias introduced...
This work presents a methodology for finding phenotype candidate genes starting from a set of known related genes. This is accomplished by automatically mining and organizing the available scientific literature using Gene Ontology-based semantic similarity. As a case study, Brugada syndrome related genes have been used as input in order to obtain a list of other possible candidate genes related with...
An effective data representation methodology on high-dimension feature spaces is presented, which allows a better interpretation of subjacent physiological phenomena (namely, cardiac behavior related to cardiovascular diseases), and is based on search criteria over a feature set resulting in an increase in the detection capability of ischemic pathologies, but also connecting these features with the...
Finding association between genotypic differences and disease traits has become one of the main objectives in current genetic research. It has been published that some of the underlying factors in the dynamics of the coagulation process have a genetic compound, showing significant hereditability. This is the case of the Factor VII. In this work, we propose a method for selecting sets of Single Nucleotide...
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