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The Na+/H+-exchanger NHE1 and the monocarboxylate transporters MCT1 and MCT4 are crucial for intracellular pH regulation, particularly under active metabolism. NHE1, a reversible antiporter, uses the energy provided by the Na+ gradient to expel H+ ions generated in the cytosol. The reversible H+/lactate− symporters MCT1 and 4 cotransport lactate and proton, leading to the net extrusion of lactic acid...
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