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We investigated the role of CD4 + and CD8 + T subsets as well as T cell cytolytic effector mechanisms in the aortic allograft model of allograft vasculopathy using CD4 and CD8 gene knockout mice (CD4 −/− , CD8 −/− ) and mice deficient in cytolytic effector pathways. Medial apoptosis at 2 weeks was reduced in CD8 −/− mice and in mice where cytotoxic T cell activity...
Allograft vasculopathy (AV) has emerged as the major obstacle to long-term survival in clinical heart transplantation. Immune events are implicated in the development of AV, but the cellular and molecular mechanisms involved remain unclear. We sought to determine whether and by what mechanism CD8 + T lymphocytes are able to generate AV in a murine aortic allograft model.Allo-primed CD8 ...
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