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In vitro treatment of macrophages with prolactin (PRL) was found to increase the production of nitric oxide (NO) and interleukin-1 (IL-1). Production of NO and IL-1 by macrophages got additively enhanced on simultaneous treatment with LPS and PRL. The production of NO was, however, decreased when the macrophages were treated with a combination of PRL and nifedipine, a Ca 2+ blocker indicating...
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