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Bradykinin causes vasodilatation by stimulating the production of vasodilator prostanoids and nitric oxide (NO). However, there is an additional component that is mediated by a diffusible endothelium-derived hyperpolarizing factor (EDHF). The non-selective inhibitor of arachidonic acid metabolism eicosatetraynoic acid inhibits the EDHF-mediated component of the relaxation to bradykinin. Therefore,...
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