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Background: Endothelial dysfunction is an early event leading to atherosclerosis. It also occurs after orthotopic heart transplantation and can be used to predict the development of intimal hyperplasia in the coronary artery wall. The present study was designed to assess the time course and specific alterations underlying endothelial dysfunction due to rejection after heart transplantation. Methods:...
Objective: The aim was to evaluate the effect of the combined 5-hydroxytryptamine-2 (5-HT 2 ) receptor antagonist and calcium channel inhibitor LU49938 ((2S)-5-[N-methyl-N-(n-hexyl)] amino-2-isopropyl-2(3.4.5-trimethoxyphenyl)-valeronitrilhydrochloride) on the endothelium dependent responsiveness of procine coronary arteries with native and regenerated endothelium. Methods: Male Yorkshire...
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