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Although aluminum (Al) is known to be toxic, the exact molecular events that enable this trivalent metal to be involved in various diseases have not been fully delineated. In this report, we show that Al promotes the translocation of the HIF-1α (hypoxia inducible factor) to the nucleus and activates the anaerobic metabolism of D-glucose. Al-exposed hepatocytes (HepG2 cells) showed a marked increase...
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