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Oral formulation of quinine is of great potential interest in uncomplicated malaria, especially in chloroquine-resistant strains. As a preliminary step to efficacy and safety studies in children, 3 studies were undertaken with a new formulation of quinine in white young healthy adults at the therapeutic dose of 25 mg/kg/d divided in 3 doses.Methods. In 2 randomised cross-over design trials, the...
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