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Polyunsaturated fatty acids (PUFAs) have neuroprotective effects against ischemic brain diseases. The newly discovered potassium channel “TREK-1” is a promising target for therapies against neurodegeneration. Arachidonic acid (AA) is an n-6 PUFA, as well as a potent TREK-1 activator. We previously showed that TREK-1 is expressed at high levels in astrocytes. However, the effect of AA on astrocytes...
The present study investigates the neurological protective effects of edaravone against global brain ischemia. Gerbils were treated with edaravone (3mg/kg; i.p.) 30min before transient forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5min. The effects of edaravone were examined by measuring neuronal damage and behavioral deficits. Hexanoyl-lysine adduct (HEL)...
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