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In the spring of 1981 the epidemic that came to be known as toxic oil syndrome (TOS) was first identified in Spain. Ultimately, more than 20,000 people were affected. Several early epidemiologic studies were aimed at identifying the causative agent of TOS, including studies in Navas del Marques, Avila. The pivotal study was done in a pediatric hospital in Madrid, and identified the causative agent...
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