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Heparin-retinoic acid (HR) and heparin-folic acid-retinoic acid (HFR) amphiphilic bioconjugates were synthesized for the development of an actively targeted drug delivery system for cancer therapy. The HR and HFR bioconjugates were synthesized by chemical conjugation via amide linkages of the carboxyl groups of heparin and the amine groups of aminated retinoic acid (RA) and aminated folic acid (FA)...
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