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The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl − channel critically important in Cl − secreting epithelia. Mutations in the CFTR gene, such as ΔF508 CFTR leads to cystic fibrosis, a severe disease with defective Cl − secretion. CFTR is stimulated by the serum and glucocorticoid-inducible kinase SGK1. The SGK1 dependent regulation...
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