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The effect of five lignans isolated from Hernandia nymphaeifolia on estrogenic compounds (17β-estradiol, tamoxifen and clomiphene)-induced Ca 2+ mobilization in human neutrophils was investigated. The five lignans were epi-yangambin, epi-magnolin, epi-aschantin, deoxypodophyllotoxin and yatein. In Ca 2+ -containing medium, the lignans (50-100 μM) inhibited 10 μM 17β-estradiol-...
The effect of five lignans, epi-aschantin, epi-magnolin, epi-yangambin, deoxypodophyllotoxin and yatein, isolated from Hernandia nymphaeifolia on Ca 2+ signaling in Madin-Darby canine kidney cells was examined using fura-2 as a Ca 2+ indicator. These lignans at concentrations between 10 and 100 μM increased [Ca 2+ ] i in a concentration-dependent manner...
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