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The role of the p53-genetic background in the expression of genes involved in either cell cycle checkpoint activation or apoptosis was evaluated in p53+/+ and p53+/− mouse strains at both basal levels and after DNA-induced damage.The spleen, colon, kidneys, lungs and liver of both strains were harvested from untreated animals and from mice exposed to 7.5Gy of X-rays and sacrificed after 5h.No significant...
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