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Genetic variation at HLA‐DRB1 is a risk factor for visceral leishmaniasis (VL) caused by Leishmania donovani. The single nucleotide polymorphism rs9271252 upstream of the DRB1 gene provides a perfect tag for protective versus risk HLA‐DRB1 four‐digit alleles. In addition to the traditional role of the membrane‐distal region of HLA class II molecules in antigen presentation and CD4 T‐cell activation,...
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