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Photodynamic therapy (PDT) is an effective approach for treating melanoma. However, the photosensitizers employed in PDT can accumulate in healthy tissues, potentially causing harm to normal cells and resulting in side effects such as heightened photosensitivity. To address this, an activatable photosensitizer (PSD) by linking PpIX with a fluorescence quencher using a disulfide bond is designed. PSD...
Cancerous cells exhibit overexpression of multiple enzymes in various cellular compartments. These enzymes are often undruggable, yet display unique advantages in regulating intracellular self‐assembly and dis‐assembly of small molecules for cancer targeting. Herein, a self‐assembling molecule (LND‐1p‐ES) for carrier‐free delivery of lonidamine specifically to cancerous cells is designed, where LND‐1p‐ES...
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