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A library of 117 chalcones was screened for efflux pump inhibitory (EPI) activity against NorA mediated ethidium bromide efflux. Five of the chalcones (5–7, 9, and 10) were active and two chalcones (9 and 10) were equipotent to reserpine with IC 50 -values of 9.0 and 7.7μM, respectively. Twenty chalcones were subsequently proved to be inhibitors of the NorA efflux pump in everted membrane...
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