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In the present study, we assessed whether concurrent treatment with low doses of cilostazol and donepezil effectively improve memory deficits in association with amelioration of the pathological changes in the white matter of rats subjected to permanent ligation of bilateral common carotid arteries (BCCAL). The escape latency in Morris water maze test was significantly increased at 7, 14 and 21 days...
This study shows that cilostazol displayed a potent inhibition of PARP with IC 50 of 883±41 nM in the enzyme assay, and also significantly reversed H 2 O 2 -evoked elevated PARP activity and reduced NAD + levels in the PC12 cells with improvement of cell viability. In in vivo study, inhibition of PARP activity by cilostazol prevented cerebral ischemic injury induced...
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