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Background
Psychiatric disorders have been associated with advanced epigenetic age in DNA methylation, yet this relationship has not been studied in the brain transcriptome. We examined transcriptomic age using an RNA‐based algorithm recently developed by Ren and Kuan (“RNAAgeCalc”) and the associations between posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and alcohol use...
Background
Posttraumatic stress disorder (PTSD) is associated with inflammation and various forms of chronic disease. The Absent in Melanoma 2 (AIM2) gene has been implicated in mechanisms of inflammation and anxiety, and methylation at a particular locus in this gene (cg10636246) has previously been shown to influence the association between PTSD and elevated C‐reactive protein levels in blood....
Given the increasing prevalence of metabolic syndrome (MetS) in males of reproductive age, the objective of this prospective case–controlled study was to investigate the impact of subacute systemic inflammation associated with MetS on seminal cytokines and standard sperm parameters in comparison with healthy men. Between 2011 and 2014, we recruited 27 patients with MetS out of 41 obese patients screened...
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