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HIV-1 virions contain approximately equal amounts of tRNA Lys,3 and tRNA Lys1,2 , yet tRNA Lys,3 has been found to be exclusively used for initiation of reverse transcription. Since previous studies have shown that even if the primer binding site (PBS) was mutated to be complementary to tRNA Lys1,2 , the virus did not stably use tRNA Lys1,2 to initiate reverse...
Previously our laboratory constructed an HIV-1 which stably maintained a primer binding site (PBS) complementary to tRNA His by mutating the region of the provirus within U5 postulated to interact with the anticodon of tRNA His (J. Wakefield, S-M Kang, and C. D. Morrow, 1996,J. Virol.70, 966–975). From the analysis of the virus obtained after long-term culture, we identified an unusual...
The complete nucleotide sequence and genome organization of oat blue dwarf marafivirus (OBDV) were determined. The 6509 nucleotide RNA genome encodes a putative 227-kDa polyprotein (p227) with sequence motifs similar to the methyltransferase, papain-like protease, helicase, and polymerase motifs present in the nonstructural proteins of other positive strand RNA viruses. The 3′ end of the open reading...
The initiation of reverse transcription of the human immunodeficiency virus type 1 (HIV-1) genome requires cellular tRNA Lys,3 as a primer and occurs at a site in the viral RNA genome, designated as the primer binding site (PBS), which is complementary to the 3′-terminal 18 nucleotides of tRNA Lys,3 . We previously described an HIV-1 virus [designated as HXB2(His-AC)], which contained...
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