Search results for: Kenneth M. Baker

Items from 1 to 20 out of 31 results

article

Loss of myocardial retinoic acid receptor α induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice

Sen Zhu, Rakeshwar S. Guleria, Candice M. Thomas, Amanda Roth, more

Journal of Molecular and Cellular Cardiology > 2016 > 99 > C > 100-112

Retinoic acid receptor (RAR) has been implicated in pathological stimuli-induced cardiac remodeling. To determine whether the impairment of RARα signaling directly contributes to the development of heart dysfunction and the involved mechanisms, tamoxifen-induced myocardial specific RARα deletion (RARαKO) mice were utilized. Echocardiographic and cardiac catheterization studies showed significant diastolic...

article

Thymosin β4 Prevents Angiotensin II‐Induced Cardiomyocyte Growth by Regulating Wnt/WISP Signaling

Li Li, Rakeshwar S. Guleria, Suresh Thakur, Cheng‐Lin Zhang, more

Journal of Cellular Physiology > 231 > 8 > 1737 - 1744

Thymosin beta‐4 (Tβ4) is a ubiquitous protein with many properties relating to cell proliferation and differentiation that promotes wound healing and modulates inflammatory mediators. However, the role of Tβ4 in cardiomyocyte hypertrophy is currently unknown. The purpose of this study was to determine the cardio‐protective effect of Tβ4 in angiotensin II (Ang II)‐induced cardiomyocyte growth. Neonatal...

chapter

Novel Aspects of the Cardiac Renin–Angiotensin System

Vivek P. Singh, Kenneth M. Baker, Rajesh Kumar

The Local Cardiac Renin-Angiotensin Aldosterone System > 75-89

Involvement of the renin–angiotensin system (RAS) in human pathophysiology has expanded to include several diseases beyond a traditional role in salt and water homeostasis. In diabetes, there is significant overactivity of the RAS, which is inhibited by treatment with RAS blockers, thus decreasing diabetic complications. Activation of the RAS in diabetes includes several unique aspects, such as elevation...

article

P54 Hydrogen sulfide inhibits activation of the renin-angiotensin system in diabetic heart

Qian-Chen Yong, Christopher J. Chang, David J. Lefer, Kenneth M. Baker, more

Nitric Oxide > 2014 > 39 > Supplement > S32

Diabetic cardiomyopathy is a major contributing factor to morbidity in diabetics. A significant role of the cardiac renin-angiotensin system (RAS) in diabetic cardiomyopathy has been demonstrated clinically. Plasma levels of hydrogen sulfide (H ₂ S), which have been demonstrated to inhibit plasma renin and endothelial ACE activity, are reduced in diabetic patients. The interaction between...

article

Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats

Rakeshwar S. Guleria, Amar B. Singh, Irina T. Nizamutdinova, Tatiana Souslova, more

Journal of Molecular and Cellular Cardiology > 2013 > 57 > Complete > 106-118

Diabetic cardiomyopathy (DCM) is a significant contributor to the morbidity and mortality associated with diabetes and metabolic syndrome. Retinoids, through activation of retinoic acid receptor (RAR) and retinoid x receptor (RXR), have been linked to control glucose and lipid homeostasis, with effects on obesity and diabetes. However, the functional role of RAR and RXR in the development of DCM remains...

article

Retinoic acid protects cardiomyocytes from high glucose‐induced apoptosis through inhibition of NF‐κB signaling Pathway

Irina T. Nizamutdinova, Rakeshwar S. Guleria, Amar B. Singh, Jonathan A. Kendall, more

Journal of Cellular Physiology > 228 > 2 > 380 - 392

We have previously shown that retinoic acid (RA) has protective effects on high glucose (HG)‐induced cardiomyocyte apoptosis. To further elucidate the molecular mechanisms of RA effects, we determined the interaction between nuclear factor (NF)‐κB and RA signaling. HG induced a sustained phosphorylation of IKK/IκBα and transcriptional activation of NF‐κB in cardiomyocytes. Activated NF‐κB signaling...

article

High Glucose‐induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling

Amar B. Singh, Rakeshwar S. Guleria, Irina T. Nizamutdinova, Kenneth M. Baker, more

Journal of Cellular Physiology > 227 > 6 > 2632 - 2644

The biological actions of retinoids are mediated by nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). We have recently reported that decreased expression of RARα and RXRα has an important role in high glucose (HG)‐induced cardiomyocyte apoptosis. However, the regulatory mechanisms of HG effects on RARα and RXRα remain unclear. Using neonatal cardiomyocytes, we found that ligand‐induced...

article

Retinoic acid receptor‐mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: Role of the renin‐angiotensin system

Rakeshwar S. Guleria, Rashmi Choudhary, Takemi Tanaka, Kenneth M. Baker, more

Journal of Cellular Physiology > 226 > 5 > 1292 - 1307

Diabetes mellitus (DM) is a primary risk factor for cardiovascular diseases and heart failure. Activation of the retinoic acid receptor (RAR) and retinoid X receptor (RXR) has an anti‐diabetic effect; but, a role in diabetic cardiomyopathy remains unclear. Using neonatal and adult cardiomyocytes, we determined the role of RAR and RXR in hyperglycemia‐induced apoptosis and expression of renin‐angiotensin...

article

Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules

Sandeep Kumar, Rachid Seqqat, Sravanthi Chigurupati, Rajesh Kumar, more

Free Radical Biology and Medicine > 2011 > 50 > 1 > 206-215

Myocardial remodeling denotes a chronic pathological condition of dysfunctional myocardium that occurs in cardiac hypertrophy (CH) and heart failure (HF). Reactive oxygen species (ROS) are major initiators of excessive collagen and fibronectin deposition in cardiac fibrosis. Increased production of ROS and nuclear factor κB (NF-κB) activation provide a strong link between oxidative stress and extracellular...

article

The intracellular renin-angiotensin system in the heart

Rajesh Kumar, Vivek P. Singh, Kenneth M. Baker

Current Hypertension Reports > 2009 > 11 > 2 > 104-110

Recently, several novel aspects of the renin-angiotensin system (RAS) were described, which potentially may change the therapeutic strategy to treat cardiovascular disease, in addition to enhancing understanding of this system’s mechanism of action. Most notably, identification of a functional intracellular RAS may address several unanswered questions regarding a direct role of angiotensin (Ang) II...

article

The intracellular renin–angiotensin system: a new paradigm

Rajesh Kumar, Vivek P. Singh, Kenneth M. Baker

Trends in Endocrinology & Metabolism > 2007 > 18 > 5 > 208-214

More than a century after its discovery, the physiological implications of the renin–angiotensin system (RAS) continue to expand, with the identification of new components, functions and subsystems. These advancements have led to better management and understanding of a broad range of cardiovascular and metabolic disorders. The RAS has traditionally been viewed as a circulatory system, involved in...

article

Kinase inhibitors for cardiovascular disease

Rajesh Kumar, Vivek P. Singh, Kenneth M. Baker

Journal of Molecular and Cellular Cardiology > 2007 > 42 > 1 > 1-11

Over the last decade, there has been substantial progress toward understanding the pathophysiology and treatment of cardiovascular diseases (CVDs). Elucidating cellular responses to the extracellular environment and signal transduction mechanisms have provided the opportunity to explore novel molecular therapeutic approaches for the treatment of CVDs. Neurohormonal stimulation has been implicated...

article

Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: Role in regulation of the local renin-angiotensin system

Sandhya Sanghi, Rajesh Kumar, Manuela Smith, Kenneth M. Baker, more

Regulatory Peptides > 2005 > 132 > 1-3 > 1-8

There is an inverse relationship between renin and atrial natriuretic peptide (ANP) levels in the plasma. Since both the ANP and renin-angiotensin system (RAS) are upregulated in development and cardiac hypertrophy, we tested whether ANP differentially regulates RAS in cardiac cells. Cardiac fibroblasts isolated from neonatal rats were treated with ANP _1–28 , a biologically active fragment...

article

Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy

Kenneth M. Baker, Mitchell I. Chernin, Taylor Schreiber, Sandhya Sanghi, more

Regulatory Peptides > 2004 > 120 > 1-3 > 5-13

Angiotensin II (Ang II) has a significant role in regulating cardiac homeostasis through humoral, autocrine and paracrine pathways, via binding to the plasma membrane AT ₁ receptor. Recent literature has provided evidence for intracrine growth effects of Ang II in some cell lines, which does not involve interaction with the plasma membrane receptor. We hypothesized that such intracrine mechanisms...

article

Agonist-dependent internalization of the angiotensin II type one receptor (AT ₁ ): role of C-terminus phosphorylation in recruitment of β-arrestins

Chris E. Kule, Vijaya Karoor, Jonathan N.E. Day, Walter G. Thomas, more

Regulatory Peptides > 2004 > 120 > 1-3 > 141-148

β-Arrestins play a role in AT ₁ endocytosis by binding the cytoplasmic, C-terminus region T332-S338, the major site of angiotensin II (Ang II)-induced phosphorylation. However, the processes responsible for recruiting β-arrestin to the activated receptor are poorly defined. In this study, we used CHO-K1 and HEK 293 cells expressing wild-type or mutant AT ₁ to investigate two possibilities:...

article

1029-176 Rescue of internalization-impaired angiotensin II AT1 mutants by β-arrestin overexpression

Chris E Kule, Vijaya Karoor, Jonathan N.E Day, Walter G Thomas, more

Journal of the American College of Cardiology > 2004 > 43 > 5(S2) > A455-A456

article

Angiotensin receptor type 1 (AT1) independent growth effects of intracellular angiotensin II (Ang II) in cardiac myocytes

Rajesh Kumar, Sandhya Sanghi, Kenneth M. Baker, David E. Dostal

Journal of the American College of Cardiology > 2003 > 41 > 6(S1) > 273

article

Erratum to ''Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: Role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure'' [J Mol Cell Cardiol 2002;34:1443-1453]

George W. Booz, Jonathan N.E. Day, Kenneth M. Baker

Journal of Molecular and Cellular Cardiology > 2003 > 35 > 2 > 225

article

Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation

George W. Booz, Jonathan N. E. Day, Kenneth M. Baker

Basic Research in Cardiology > 2003 > 98 > 1 > 33-38

Abstract. Experiments were performed to define the basis for negative regulation of STAT3 activation (i.e., Tyr705 phosphorylation) by angiotensin II in cardiomyocytes. Treatment of cardiomyocytes with angiotensin II resulted in rapid and sustained phosphorylation of STAT3 on Ser727; in contrast, STAT3 Tyr705 phosphorylation was decreased, with dephosphorylation being most pronounced at 30 minutes...

article

Interplay Between the Cardiac Renin Angiotensin System and JAK-STAT Signaling: Role in Cardiac Hypertrophy, Ischemia/Reperfusion Dysfunction, and Heart Failure

George W. Booz, Jonathan N.E. Day, Kenneth M. Baker

Journal of Molecular and Cellular Cardiology > 2002 > 34 > 11 > 1443-1453

G. W. Booz, J. N. E. Day and K. M. Baker. Interplay Between the Cardiac Renin Angiotensin System and JAK-STAT Signaling: Role in Cardiac Hypertrophy, Ischemia/Reperfusion Dysfunction, and Heart Failure. Journal of Molecular and Cellular Cardiology (2002) 34, 1443–1453. Recent studies have shown that the JAK-STAT signaling pathway plays a central role in cardiac pathophysiology. JAK-STAT signaling...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Kenneth M. Baker

Loss of myocardial retinoic acid receptor α induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice

Thymosin β4 Prevents Angiotensin II‐Induced Cardiomyocyte Growth by Regulating Wnt/WISP Signaling

Novel Aspects of the Cardiac Renin–Angiotensin System

P54 Hydrogen sulfide inhibits activation of the renin-angiotensin system in diabetic heart

Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats

Retinoic acid protects cardiomyocytes from high glucose‐induced apoptosis through inhibition of NF‐κB signaling Pathway

High Glucose‐induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling

Retinoic acid receptor‐mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: Role of the renin‐angiotensin system

Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules

The intracellular renin-angiotensin system in the heart

The intracellular renin–angiotensin system: a new paradigm

Kinase inhibitors for cardiovascular disease

Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: Role in regulation of the local renin-angiotensin system

Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy

Agonist-dependent internalization of the angiotensin II type one receptor (AT ₁ ): role of C-terminus phosphorylation in recruitment of β-arrestins

1029-176 Rescue of internalization-impaired angiotensin II AT1 mutants by β-arrestin overexpression

Angiotensin receptor type 1 (AT1) independent growth effects of intracellular angiotensin II (Ang II) in cardiac myocytes

Erratum to ''Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: Role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure'' [J Mol Cell Cardiol 2002;34:1443-1453]

Angiotensin II effects on STAT3 phosphorylation in cardiomyocytes: evidence for Erk-dependent Tyr705 dephosphorylation

Interplay Between the Cardiac Renin Angiotensin System and JAK-STAT Signaling: Role in Cardiac Hypertrophy, Ischemia/Reperfusion Dysfunction, and Heart Failure

Filter options

Publication date

Content availability

Publication type

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Kenneth M. Baker

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Publication type

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options