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The definition of immune memory after hepatitis B vaccination is still under debate. Therefore, we analysed hepatitis B surface antigen (HBsAg)-specific memory in more detail by investigating the kinetics of humoral and cellular responses after hepatitis B booster vaccination.The anti-HBs kinetics of 23 individuals with anti-HBs titres below 10IU/l, who had been vaccinated 10–15 years ago, was monitored...
Institutionalized mentally retarded subjects are well-known to be at-risk for HBV infection. We studied the persistence of vaccine-induced anti-HBs antibodies and the robustness of the HBsAg-specific immune memory in this population, 18–20 years after the first vaccine dose.Non-immune residents of 4 institutions were immunized in 1984–1986. In 2004, 207 subjects were bled to determine humoral and...
Long-term protection after hepatitis B vaccination is dependent on the persistence of a strong immunologic memory. In search of reliable markers for a hepatitis B surface antigen (HBsAg)-specific immunological memory we studied the cellular and humoral immune responses of 15 healthy individuals who were successfully vaccinated but had lost anti-HBs titers.To determine the reactivity of vaccine-induced...
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